Toggle geojson layer interactivity - leaflet

Question

First of all, since it's my first question, I'm sorry if I make any mistakes.
I'd like to "deactivate" a Geojson Layer, composed by a feature collection with many polygons (or lines). I have seen how to create it with the option interactive = yes or interactive = no, but I can't find out how to toggle this dynamically.
Thanks in advance.
EDIT: last thing I tried was this:
var onEachFeature = function(feature, layer) {
function onmouseover(e) {
var layer = e.target;
var activeLayer = ___get_active_layergroup();
if (activeLayer === null){
layer.setStyle({
cursor: 'move'
});
} else if (activeLayer.hasLayer(layer)){
layer.setStyle({
cursor: 'pointer'
});
} else {
layer.setStyle({
cursor: 'move'
});
}
}
function onmouseout(e) {
}
return {
mouseover: onmouseover,
mouseout: onmouseout
}
}
And I put that function in the layer initialization.
___get_active_layergroup is accesible in the context.
EDIT2:
It works if instead of setStyle I use this:
var element = layer.getElement();
if (element.classList.contains("leaflet-interactive")) {
element.classList.remove("leaflet-interactive")
}
But I don't really like how it works. I can see the pointer while I'm moving the mouse blinking (because it takes a few milliseconds process the mouseover I think).